The family of P-450 enzyme systems is quite diverse, with specific enzyme systems being inducible by particular drugs, toxins or metabolites. It is this characteristic that has allowed the development of special tests to check the function of the various pathways.
The higher the doses used, the more likely it is that withdrawal symptoms will be severe. A comorbid dependence on drugs and alcohol can create a unique constellation of withdrawal symptoms, which might exacerbate one another.
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